Mutation is a sound-based composition for amplified clarinet with a synthetic reed and fixed electronics. In Mutation, I developed a new ultra-thin synthetic reed for clarinet using laser-cut, 3D printing and casting technologies. Furthermore, I developed a number of new sound possibilities and performance techniques using the novel reed. I proposed notational solutions for these techniques and appropriate documentation that explain them. The electronic part bridges the new sounds with soundscape formations and associations. Mutation has been commissioned for the EXPO2015 and the Divertimento Ensemble in Milan/ Italy. Mutation features some of the results of my previous research on new instrumental sound possibilities. It incorporates a variety of composition models, which are based on sound-to-sound structures, on transformation strategies from one sound to another as well as on functional classification sound models.